VENTANA ALK (D5F3) CDX assay is now an FDA approved in vitro diagnostic test (PMA) to identify ALK-positive, non-small cell lung cancer (NSCLC) patients eligible for treatment with Alecensa® (alectinib).

Tissue Reagents Lung Pathology

Lung Pathology

Contact a Rep HTML

Request more information about Lung Pathology products.

Please complete the form below to speak with a Roche representative.

 
 
 
 
 
 
 
 
 
Overview

The statistics associated with lung cancer clearly demonstrate the aggressive nature of this deadly disease. Roche offers you a robust menu of tools to aid in the diagnosis of patients facing this challenge. Our portfolio of products delivers the high sensitivity and specificity you need from your assays.

Our antibodies are ready to use on the fully automated VENTANA BenchMark IHC/ISH staining platforms, reducing the time-to-result and resources required with manual or semi-automated solutions. VENTANA prediluted, optimized reagents consistently demonstrate superior performance when compared to concentrated antibodies that require manual dilution and in-house validation.1

Disease State Diagnostic Toolkit:
Lung Cancer

More than half of the people diagnosed with lung cancer die within one year.
> Learn more
Gain a clear view with the VENTANA ALK (D5F3) assay

VENTANA ALK (D5F3) CDx Assay is intended for the qualitative detection of the anaplastic lymphoma kinase (ALK) protein in formalin-fixed, paraffin-embedded (FFPE) non-small cell lung carcinoma (NSCLC) tissue stained with a BenchMark XT or BenchMark ULTRA automated staining instrument. It is indicated as an aid in identifying patients eligible for treatment with XALKORI®, ZYKADIA®, and ALECENSA®.

Rest assured—your solution for lung cancer diagnostics is here

p40 (BC28) Mouse Monoclonal Primary Antibody is a ready-to-use IHC antibody that enables you to evaluate the expression of p40 (ΔNp63) protein with clinical confidence using the OptiView DAB IHC Detection Kit.

p40 (BC28) is shown to be as sensitive as p63 (4A4) in non-small cell lung cancer but more specific. We recommended the use of p40 instead of p63 for subclassifying non-small cell lung cancer to avoid falsely interpreting p63+ adenocarcinoma as belonging to the category of squamous cell carcinoma.2

In a panel with other key markers in our portfolio (TTF-1, CK 5/6, Napsin A), p40 (BC28) can help you confidently differentiate between lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC).3

References
1. Assessment Run B13 2012. Estrogen receptor (ER). NordiQC. http://www.nordiqc.org/Run-35-B13-H1/Assessment/assessment-B13-ER.htm. Updated 10 JUL 2012. Accessed 23 MAY 2013.
2. Bishop, Justin A, Julie Teruya-Feldstein, William H Westra, Giuseppe Pelosi, William D Travis and Natasha Rekhtman. p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma. Modern Pathology. 2012.
3. Wei Zhao, Hui Wang, Yan Peng, Bo Tian, Lei Peng, Da-Chuan Zhang. ΔNp63, CK5/6, TTF-1 and napsin A, a reliable panel to subtype non-small cell lung cancer in biopsy specimens. Int J Clin Exp Pathol 2014;7(7):4247-4253.

Menu

assay menu

Outside of Pepper mode, this text will be replaced by the Assay Menu.

Lorem Ipsum
Dolor Sit
...
Resources

Outside of Pepper mode, this text will be replaced by the resource cards.

Contact Us

Outside of Pepper mode, this text will be replaced by the content added in the above "Contact a Rep HTML" code editor.

Lung Pathology

ALK (D5F3) CDx Assay, VENTANA
BG8, Lewisy (F3)
Calretinin (SP65) Rabbit Monoclonal Primary Antibody,CONFIRM
Caveolin-1 (SP43) Rabbit Monoclonal Primary Antibody
CD56 (MRQ-42)
CEA (CEA31) Mouse Monoclonal Antibody
CEA (TF 3H8-1) Primary Antibody
Chromogranin A (LK2H10) Primary Antibody
Cytokeratin 5 (SP27) Rabbit Monoclonal Primary Antibody
Cytokeratin 5/6 (D5/16B4) Mouse Monoclonal Primary Antibody
Cytokeratin 5/14 (EP1601Y/LL002) Rabbit and Mouse Monoclonal Primary Antibody
Cytokeratin 7 (SP52) Rabbit Monoclonal Primary Antibody, CONFIRM
Cytokeratin 20 (SP33) Rabbit Monoclonal Primary Antibody, CONFIRM
Desmoglein 3 (5G11) Mouse Monoclonal Primary Antibody
DLL3 (SP347) Assay
E-cadherin (36) Mouse Monoclonal Primary Antibody, VENTANA
E-Cadherin (EP700Y)
EGFR (3C6) Primary Antibody, CONFIRM
EGFR (5B7) Rabbit Monoclonal Primary Antibody, CONFIRM
EGFR E746-A750 del (SP111) Rabbit Monoclonal Primary Antibody
EGFR L858R (SP125) Rabbit Monoclonal Primary Antibody
EMA (E29) Mouse Monoclonal Primary Antibody, CONFIRM
Ep-CAM (Ber-EP4)
Epithelial Related Antigen (MOC-31) Mouse Monoclonal Primary Antibody
HBME-1 (HBME-1)
IGF-1R (G11) Rabbit Monoclonal Primary Antibody, CONFIRM
Ki-67 (30-9) Rabbit Monoclonal Primary Antibody, CONFIRM
MSLN (SP74) Assay, VENTANA
MUC1 (H23) Mouse Monoclonal Primary Antibody
Napsin A (MRQ-60) Mouse Monoclonal Primary Antibody
Napsin A (polyclonal)
p40 (BC28) Mouse Monoclonal Primary Antibody
p63 (4A4) Mouse Monoclonal Primary Antibody, VENTANA
Pan Keratin (AE1/AE3/PCK26) Primary Antibody
PD-L1 (SP142) Assay, VENTANA
PD-L1 (SP263) Rabbit Monoclonal Primary Antibody, VENTANA
SOX-2 (SP76)
Synaptophysin (MRQ-40) Rabbit Monoclonal Antibody
Synaptophysin (SP11) Rabbit Monoclonal Primary Antibody, CONFIRM
TAG-72 (B72.3)
Thyroid Transcription Factor-1 (8G7G3/1) Mouse Monoclonal Primary Antibody, CONFIRM
Thyroid Transcription Factor-1 (SP141) Rabbit Monoclonal Primary Antibody
Total c-MET (SP44) Rabbit Monoclonal Primary Antibody, CONFIRM
WT1 (6F-H2)