The cobas® Liat® PCR System

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When there is a pressing need for a diagnosis and a treatment decision, patients rely on you and your staff for the most responsive, trustworthy medical attention available.

The Roche cobas Liat PCR System allows you to detect and identify Influenza A/B and Strep A—in your own clinic, using advanced Roche PCR technology previously available only to complex molecular laboratories.

The cobas Liat System is small, easy to use and fast—able to provide accurate results by the end of a patient’s appointment.

And there is minimal training required.

The cobas Liat System is on-site molecular testing you can depend on. For the patients who depend on you.

Explore the cobas® Liat® PCR System

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Unparalleled accuracy in diagnostic testing

. . . now at physicians' fingertips

Since 1983, Roche has pioneered the advancement of polymerase chain reaction (PCR) analysis, now recognized as a gold standard in laboratory diagnostics.

  • Proprietary, Nobel Prize-winning technology
  • Identifies infectious diseases by replicating DNA or RNA extracted from small patient samples
  • Extraordinary sensitivity and specificity across assays significantly reduces the risk of false negatives and false positives*

*Data on file


Recognized as one of the most important scientific advances of the 20th century1, polymerase chain reaction (PCR) is a quick, easy way to create unlimited copies of DNA from just one original strand.

1. Mark R. Hughes, deputy director of the National Center for Human Genome Research at the National Institutes of Health (perhaps better known as the Human Genome Project).

The cobas Liat System for results-oriented patient care

In large molecular laboratories, PCR analysis is performed on many samples simultaneously—a multi-step process requiring a skilled technician.

The cobas Liat System fully automates these steps for the rapid analysis of a single sample, making it ideal for time-sensitive in-office diagnoses.

No operator intervention or interpretation required.

  • Each cobas Liat assay tube contains a set of chemical reagents used in the detection of DNA or RNA sequences unique to a particular infectious disease
  • Inside the cobas Liat Analyzer, pressure and heat are precisely applied to the tube segments, mixing the sample and reagents in a prescribed sequence
  • DNA or RNA from within the sample is amplified and analyzed to detect and identify disease
  • An accurate positive or negative result is generated in 20 minutes or less

Working Principle

The cobas Liat Analyzer compresses the assay tube to selectively release reagents from tube segments, move the sample from one segment to another, and control reaction conditions at different temperatures.

Workflow Simplified

 System self-check

  • At power-on
  • Configuration check
  • Ambient temperature check and lock out

 Error-diagnostic system

  • Comprehensive real-time monitoring
  • Continuous self-calibration
  • Error messages displayed and recorded
Designed for afail safe experience

 Sample and quality control

  • Volume sensing to ensure appropriate amount of sample is used
  • Internal Control pre-packed and processed through every step
  • Quality control reagents provided with each new assay tube lot
  • Automated reagent lot recognition and control
  • Completely closed system

 Operator controls

  • Mandatory operator name and PIN entry
  • Mandatory patient sample identifier
  • User lock-out features