COBAS® AmpliPrep / COBAS® TaqMan® system

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Overview

Flexibility. Efficiency. Confidence.

Discover a new benchmark in efficiency


At Roche, we believe that before we can make a difference in the lives of patients, we need to make a difference in the lives of our customers. It has been the driving principle of our pioneering work in viral load monitoring since 1996.

 

From our proven heritage of leadership to our continued commitment to innovation, our experience gives you greater flexibility, increased efficiency and enhanced data integrity for your laboratory. You can have confidence to stand behind—and take pride in—your work. When that happens, we have made a difference.

 

In the real-time PCR era, COBAS® AmpliPrep / COBAS® TaqMan® Systems have been trusted to perform more than 85 million tests worldwide.*

 

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*Data as of the end of 2012

COBAS AmpliPrep / COBAS TaqMan
Features

Designed for viral load monitoring.

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COBAS® AmpliPrep instrument

Full automation, continuous loading, in a configuration that fits your lab
Because no two labs are the same, we designed our system to provide multiple configuration options with flexibility in processing modes. Flexibility means the system can expand and adapt to your workflow and operational changes. From docked instrumentation to linked format, small to large volume workflow, batch or continuous loading mode, the system makes viral load monitoring practical for every lab.


Flexible throughput capacity

  • Results for 9–21 patient samples per rack without reagent waste
  • Run a total of 147 patient samples within an 8-hour shift
  • Overnight operation with the docked system for expanded throughput

COBAS® Taqman® analyzer or COBAS® Taqman® 48 analyzer

Reliable assay performance

  • FDA approved for four viral load monitoring assays (HIV-1, HCV, HBV and CMV)
  • Broad dynamic range minimizes the need for repeat testing or dilutions
  • High precision and sensitivity to deliver the standard of care for viral load monitoring
  • Extensive clinical and analytical data for each assay in every package insert to support your verification testing
  • Global surveillance program for monitoring of viral sequence changes


Integrity of results

  • Ready-to-use, bar-coded, and calibrated reagent cassettes
  • Proprietary AmpErase enzyme prebuilt into every reaction
  • Closed-tube processing and dedicated consumables to minimize contamination and protect the integrity of your samples
  • Quantitation standard included in every reaction for internal calibration and control
  • Approved for single room operation
  • Clot detection and input-volume surveillance for dependable self-monitoring
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cobas p 630 instrument (optional)

Pre-analytical, fully automated patient tube handling
Experience increased productivity with a pre-analytical, fully automated solution for patient tube handling. Designed to reduce hands-on time and further improve laboratory efficiency, the state-of-the-art cobas p 630 instrument improves your laboratory’s productivity while also providing the security that only comes from robotic assurance.


Efficient

  • Transfer of patient samples from primary or secondary transport tubes to s-input tubes
  • De-capping and capping of s-input tubes
  • Mixing and pipetting of Roche controls


Flexible

  • Single cobas p 630 instrument supports up to 3 COBAS® AmpliPrep/COBAS® TaqMan® systems in various configurations
  • Compatible with a variety of tube sizes and dimensions
  • Capacity for up to 320 patient tubes loaded on deck
  • Transfers up to 157 patient samples/hour


Integrity

  • Maintain integrity of patient samples with separate pre-analytical handling
  • Positive ID sample tracking from patient tube through to result
  • Process surveillance technologies for monitoring of liquid handling performance
  • Bi-directional connectivity between LIS, AMPLILINK software and cobas p 630 instrument
Specifications

Specifications

Instrument/Analyzer cobas p 630 (optional)           COBAS® AmpliPrep COBAS® TaqMan® COBAS® TaqMan® 48
Description State of the art, automated pre-analytical primary and secondary tube handling Closed-tube, fully automated sample preparation and PCR set-up that processes clinical specimens sequentially in a continuous flow Fully automated amplification and detection of nucleic acids for run sizes up to 96 samples Fully automated benchtop amplification and detection of nucleic acids for run sizes up to 48 samples
Physical Dimensions (W x D x H) 44” x 40” x 66”, 308 lbs 65” x 29” x 37”, 683 lbs 45” x 30” x 37”, 485 lbs 18” x 30” x 20”, 121 lbs
Electrical Power Requirements Line Voltage: 115 VAC (-15%) to 230 VAC (+10%)
Frequency: 50 or 60 Hz (+ 5%)
Power Consumption: 600 VA
Line Voltage: 100 - 125 VAC (+10%; -15%)
Frequency: 50 or 60 Hz (+ 2 Hz)
Power Consumption: 1000 VA
Line Voltage: 100 - 125 VAC (+10%; -15%)
Frequency: 50 or 60 Hz (+ 2 Hz)
Power Consumption: 800 VA
Line Voltage: 100 - 125 VAC (+10%; -15%)
Frequency: 50 or 60 Hz (+ 2 Hz)
Power Consumption: 600 VA
Interface cobas p 630 data station is connected to the AMPLILINK server data station through an Ethernet LAN AMPLILINK software has bidirectional ASTM 2.0 interface capabilities using RS-232 or TCP/IP connection for uploading and downloading using a single data station streamlining the interface with your LIS Analyzer is connected through Ethernet LAN and managed from the single AMPLILINK data station Analyzer is connected through Ethernet LAN and managed from the single AMPLILINK data station
Contamination Control Features Maintains sample integrity of patient samples with separate pre-analytical handling:
Positive ID sample tracking, anti-droplet control, aerosol barrier tips, Total Aspiration and Dispense Monitoring
Closed-tube sample preparation with dedicated consumables and pipette tips. UV light is mounted inside of instrument for decontamination at the end of the day Independent reagent pipetting system separated from sample pipetting and processing Amplification and detection reagents are in ready-to-use, sealed, barcode-labeled cassettes. Analyzer utilizes locked K-tubes for amp/detect. AmpErase and dUTP are built into reagent Master Mix Amplification and detection reagents are in ready-to-use, sealed, barcode-labeled cassettes. Analyzer utilizes locked K-tubes for amp/detect. AmpErase and dUTP are built into reagent Master Mix
Throughput Transfers up to 157 patient samples/hr Up to 147 samples per shift, continuous load and parallel processing maximizes throughput and workflow Four independently operating thermal cyclers with approximate run time of 180 minutes Two independently operating thermal cyclers with approximate run time of 180 minutes
Instrument Capacity Holds up to 320 primary tubes at one time and 6 AmpliPrep s-input tube racks 72 on board samples with 4 different reagent kits at one time 4 x 24 separate thermal cyclers allow for greater workflow flexibility 2 x 24 separate thermal cyclers allow for greater workflow flexibility

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