cobas® 4800 system

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Innovation made simple.

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Engineered for peace of mind.

Reliably automates nucleic acid purification, PCR set-up and system performance—including reporting—to provide true walkaway automation for maximum lab efficiency.

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cobas x 480 Instrument

  • Fully automated sample preparation from primary vials
  • Ready-to-use, load-and-go reagents
  • No thawing or mixing required
  • Less than 20-minute set-up for full run of 94 samples

cobas z 480 Analyzer

  • Real-time PCR with digital data capture provides accurate qualitative results with no gray zone
  • Eliminates the need for equivocal sample retesting
  • Advanced results algorithm eliminates the need for manual curve analysis



Innovation designed to optimize reliability.

Dependable performance, dependable results.


Innovation + Reliability = Confidence.

For reliable real-time PCR for medium- to high-throughput labs, the cobas 4800 system was engineered to inspire confidence. It uses the latest generation of LightCycler Technology to deliver reproducible results and represents a new standard in innovation.

CO-RE tip technology

improves sealing by securely locking pipette tips in place with an O-ring that expands smoothly to fit a specially designed groove. This O-ring gently decompresses during tip release to avoid motions that can create sample/reagent aerosols that lead to cross-contamination.

A proprietary Total Aspirate and Dispense Monitoring (TADM) system

ensures valid results by monitoring the pressure within tips to detect low volumes and clogs; pressure responses that fall outside the expected range are reported as errors

5 optical channels

to detect multiple targets from 1 reaction tube

Designed for bi-directional LIS communication 

to simplify test ordering while supporting integrity of results (no manual data entry required)

Includes remote diagnostics support

through a secure web connection, so our Service and Technical Support team can streamline troubleshooting and minimize downtime

Simplifies workflow efficiency.

Easy to learn, easy to use, easy to trust.

Streamlined design helps save time and resources

Because it requires less hands-on time than most comparable systems and needs minimal daily maintenance, the cobas 4800 system frees staff to spend more time on other critical tasks.

It accommodates multiple sample types and flexible batch sizes, and provides an easy-to-use software interface that can make operation simple even for lab techs with no molecular diagnostics experience.

For efficiency from start to finish, the cobas 4800 system:

Delivers fast results

to help meet demanding turnaround times

  • Requires < 40 minutes of hands-on time (96-sample run)
  • Reagents are ready to go, no preparation required


Features primary tube loading

to eliminate manual sample transfer steps

Enables flexible ordering

for an expanding, diverse menu of individual, combination or laboratory-developed tests

Reliable assay performance

Roche assays for the cobas 4800 system help deliver consistently reliable results because:

The proprietary AmpErase enzyme

destroys virtually all previously generated amplicon to reduce cross-contamination concerns that can lead to false-positive results

Automatic internal controls

minimize the potential for false-negative results

Each test is automatically analyzed with a unique kinetic algorithm

so results are clearly positive, negative or invalid

Innovation that gets down to business.

Delivering results that can improve patient care and your bottom line.


Position your lab for the future—today 

Because it provides trustworthy results for high-demand tests—while meeting the most demanding expectations for turnaround time—the cobas 4800 system helps you meet your facility’s: 

Operational goals

(more test results/day with less downtime) 

Clinical goals

(fast, reliable results to support therapy decisions)

Financial goals

(streamlined test requisition/cost-capture and minimum reliance on outside lab services)  


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