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Take your lab to the next level

System is comprised of the cobas c 311 clinical chemistry and cobas e 411 immunoassay analyzers. Labs running lower volumes of tests have the ability to expand operations for busier workloads. A broad selection of assays for both the clinical chemistry and immunoassay menus.

cobas c 311 analyzer

  • Uses convenient cobas c reagent packs with liquid, easy to test reagent
  • Growing test menu with more than 90 reagents
  • 3- to 10-minute test duration times
  • Combined photometric and ISE throughput up to 300 tests/hour
  • Clot and liquid level detection
  • Ultrasonic mixing of reagents and samples minimized cross-contamination from carryover
  • Real-time, remote troubleshooting service and support through cobas e-services
  • Ability to run third-party reagents
cobas c 311 analyzer

Take a deeper look at the cobas 4000 system


cobas 4000 explore: Application showcase

Designed with smaller labs in mind

cobas e 411 analyzer

cobas e 411 analyzer

  • Up to 86 tests/hour
  • Clot and liquid level detection
  • System memory of up to 2,000 results (samples and QC) that can be downloaded to a USB drive
  • Automatic sample diluation upon request
  • Windows® XP-based control unit
  • Individual and cumulative QC
  • Preprogrammable calibrators and controls

cobas® 4000 Technical Specifications

cobas c 311 analyzer

Test throughput
  • 300 photometric tests/hour
  • 450 ISE tests/hour
Number of channels 42 channels and 3 ISEs
Programmable parameters 86 photometric applications, 3 ISE applications, 3 serum indices, 8 calculated results
Sample material Serum/plasma, urine, CSF, WB (HbA1c only)
Sample input/output Disk with 108 positions for samples, calibrators and controls, plus W1 position for ISE cleaning solution, W2 position for ISE activator; user-definable STAT positions
Sample barcode types NW7 (Codabar); Code 39; ITF; Code 128
System interface RS-232C serial interface
Sample database 10,000 results (routine, STAT and QC)
Calibration methods Start-up, re-calibration for photometric assays: Linear, non-linear multi points, 2 point calibration, K-factor. Up to 100 calibrators pre-programmable, storage of up to 180 curves. Preventative calibration of standby cassettes. Two K-factors can be defined for different sample types.
QC methods Individual QC and cumulative QC. Up to 100 controls pre-programmable/Preventative QC after calibration of standby cobas c packs/Auto QC (without operator intervention).
Electrical requirements 115 Volts AC; Frequency 60 Hz +/- 0.5%
Water requirements Water Type: bacteria-free, deionized water
Water consumption ~ 12 L/hr during operation
Operating conditions Ambient room temperature of 15 to 32°C; relative humidity 30 to 85% non-condensing
Physical dimensions
  • Depth: 34 in (86.4 cm)
  • Height closed: 50 in (127 cm)
  • Height open: 67 in (170.2 cm)
  • Width: 52 in (132.1 cm)
Weight 550 lbs (250 kg)

cobas c 411 analyzer

System Fully automated, immunoassay analyzer for random access processing of ECL-based immunoassays (cobas e system format)
System components Self contained bench top analyzer comprising an analytical unit and a customized user interface
Types of modules
  • cobas e 411 disk analyzer
  • cobas e 411 rack analyzer
  • Optional System Table (cabinet); Optional System Table Extension (for printer)
System interfaces RS232 serial interface, bidirectional
Throughput Up to 86 tests/hour
Number of reagent channels 18 channels (reagent slots) for maximum of 18 tests
Programmable test parameters N/A, programming-by-loading (PBT) concept, application data are transferred without operator intervention from the 2D barcode of the reagent pack (RP) into the instrument database
Sample materials Serum/plasma, urine, others
Sample input/output
  • 30 positions for samples, calibrators and controls
  • 15 racks with 5 samples each (= 75 samples in/out)
Sample volume 10 - 50 μl.
Sample clot detection Standard (pressure sensor)
Sample barcode types Code 128; Codabar (NW 7); Interleaved 2 of 5; Code 39
Control unit Microsoft® Windows® XP-based panel PC
Calibrator/QC input cobas e system-specific barcoded CalSet vials on disk or racks
Calibration methods Lot calibration (L-cal); Reagent Pack (RP) calibration (R-Cal)
QC methods
  • Individual QC and cumulative QC
  • Up to 100 controls pre-programmable
Data storage capacity The memory contains data files necessary for the analyzer and software to work together:
  • Reagent Data File: Up to 300 reagent packs
  • Sample Data File: Up to 2000 test records (for samples and controls)
  • Calibration Data File: Up to 160 calibrators - QC Data File: Capacity up to 100 controls
  • Operating Parameter Data File: Up to 305 reagent applications
  • Up to 20 operator IDs
Electrical requirements
  • 230/110 Volts AC; 1,000 kVA (disk), 1,250 kVA (rack)
  • Frequency: 50 Hz or 60 Hz +/- 0.5%
Water/Waste requirements
  • Water: Bacteria free, de-ionized water supply, resistance of less than 10 μS/cm
  • Liquid waste: Onboard waste container (4 liter), direct drain optional
Operating conditions
  • Ambient temperature: 18 to 32°C
  • Ambient humidity: 20 to 80% RH (without condensation)
  • Heat Output: 2,879 kJ/hr (analyzer unit)
  • Noise Output: 60 dBA (stand-by), 63 dBA (operation avg.)
Physical dimensions
  • Width (disk/rack): 120 cm / 170 cm 47.2 in / 67 in
  • Depth (disk/rack): 73 cm / 95 cm 28.7 in / 37.4 in
  • Height: 80 cm / 31.4 in (closed top cover) 109 cm / 43 in (opened top cover)
  • Disk: 180 kg / 397 lbs
  • Rack: 250 kg / 551 lbs

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Strategic Resource Center Decision Guide

cobas c 311


Iron Binding Capacity - Unsaturated
Iron Gen.2
Tina-quant Ferritin Gen.4
Tina-quant Soluble Transferrin Receptor
Tina-quant Transferrin ver.2

Cardiac/Cardiac Markers

Cardiac C-Reactive Protein (Latex) High Sensitive
Cholesterol Gen.2
HDL-Cholesterol Gen.4
HDL-Cholesterol plus 3rd generation
LDL-Cholesterol Gen.3
Tina-quant Apolipoprotein A-1 ver.2
Tina-quant Apolipoprotein B ver.2
Tina-quant D-Dimer
Tina-quant Lipoprotein (a) Gen.2
Tina-quant Myoglobin Gen.2
Triglycerides/Glycerol Blanked


Tina-quant D-Dimer


Amphetamines II
Barbiturates Plus
Benzodiazepines Plus
Cannabinoids II
Cocaine II
Ethanol Gen.2
Methadone II
Opiates II
Phencyclidine Plus
Propoxyphene Plus


Glucose HK
Tina-quant Albumin Gen.2
Tina-quant Hemoglobin A1c Gen.2
Tina-quant Hemoglobin A1c Gen.3 - Hemolysate and Whole Blood Application

General Chemistry

Alanine Aminotransferase acc. to IFCC with pyridoxal phosphate activation
Alanine Aminotransferase acc. to IFCC without pyridoxal phosphate activation
Albumin BCP
Albumin Gen.2
Alkaline Phosphatase
Aspartate Aminotransferase acc. to IFCC with pyridoxal phosphate activation
Aspartate Aminotransferase acc. to IFCC without pyridoxal phosphate activation
Bicarbonate Liquid
Bilirubin Total Gen.3
Bilirubin direct
Calcium Gen.2
Cholinesterase Gen.2
Creatine Kinase
Creatine Kinase
Creatinine Jaffé Gen.2
Creatinine plus ver.2
Direct Bilirubin
Lactate Dehydrogenase acc. to IFCC ver.2
Lactate Gen.2
Lipase colorimetric assay
Magnesium Gen.2
Phosphate (Inorganic) ver.2
Total Protein Gen. 2
Total Protein Urine/CSF Gen.3
Uric Acid ver.2
a-Amylase EPS ver.2
α-Amylase EPS Pancreatic
γ-Glutamyltransferase ver.2 Standardized against IFCC / Szasz




Tina-quant Myoglobin Gen.2

Specific Proteins

C-Reactive Protein
C-Reactive Protein Gen.3
Cardiac C-Reactive Protein (Latex) High Sensitive
Homocysteine Enzymatic Assay
Immunoglobulin A
Rheumatoid Factors II
Tina-quant Antistreptolysin O
Tina-quant Complement C3c ver.2
Tina-quant Complement C4 ver.2
Tina-quant Cystatin C Gen.2
Tina-quant Haptoglobin ver.2
Tina-quant IgG Gen.2
Tina-quant IgM Gen.2
Tina-quant α1-Acid Glycoprotein Gen.2
Tina-quant α1-Antitrypsin ver.2
Tina-quant β2-Microglobulin


Mycophenolic Acid
ONLINE TDM Acetaminophen Gen.2
ONLINE TDM Carbamazepine Gen.4
ONLINE TDM Vancomycin Gen.3
Valproic Acid

cobas e 411


Folate III
Folate RBC
Folate RBC
Folate RBC Hemolyzing Reagent
Vitamin B12
Vitamin B12 II

Bone Markers

25-Hydroxyvitamin D
Elecsys Vitamin D total II
Osteocalcin (OCN)
Parathyroid hormone (parathormone, parathyrin) - PTH, intact
Parathyroid hormone (parathormone, parathyrin) - PTH, intact (STAT "Short Turn Around Time")
β-CrossLaps/serum (β-CTx in serum)

Cardiac/Cardiac Markers

CK-MB - the MB isoenzyme of creatine kinase
CK-MB - the MB isoenzyme of creatine kinase (STAT "Short Turn Around Time")
Elecsys Troponin T Gen 5 STAT
Myoglobin STAT (Short Turn Around Time)
Troponin T STAT (Short Turn Around Time), CARDIAC T
Troponin T, CARDIAC T




Dehydroepiandrosterone sulfate
Elecsys ACTH
Elecsys Prolactin II
Estradiol III
Follicle-stimulating hormone
Human sex hormone-binding globulin
Intact human chorionic gonadotropin + the β-subunit
Luteinizing hormone

General Chemistry

CK-MB - the MB isoenzyme of creatine kinase
CK-MB - the MB isoenzyme of creatine kinase (STAT "Short Turn Around Time")

Growth Hormones

Human growth hormone


Anti HCV
Antibodies to hepatitis B core antigen (anti-HBc)
Antibody to hepatitis B surface antigen (anti-HBs)
Antibody to hepatitis C virus (anti-HCV)
Elecsys Anti-HBc II
Elecsys Anti-HBc IgM
HBsAg Confirmatory Test
HBsAg Confirmatory Test
Hepatitis B surface antigen
Hepatitis B surface antigen
IgM antibodies to the hepatitis A virus
Total antibodies (IgM and IgG) to the hepatitis A virus

Infectious Disease

Cytomegalovirus IgM
IgG antibodies to Cytomegalovirus
IgG antibodies to Rubella virus
IgG antibodies to Toxoplasma gondii
IgG antibodies to herpes simplex virus type 1
IgM antibodies to Cytomegalovirus
IgM antibodies to Rubella virus
Toxo IgM

Rheumatoid Arthritis

Antibody to cyclic citrullinated peptide (anti-CCP)


CK-MB - the MB isoenzyme of creatine kinase
CK-MB - the MB isoenzyme of creatine kinase (STAT "Short Turn Around Time")
Elecsys Troponin T Gen 5 STAT
Human chorionic gonadotropin (Short Turn Around Time)
Myoglobin STAT (Short Turn Around Time)
Parathyroid hormone (parathormone, parathyrin) - PTH, intact
Parathyroid hormone (parathormone, parathyrin) - PTH, intact (STAT "Short Turn Around Time")
Troponin I STAT (Short Turn Around Time)
Troponin T STAT (Short Turn Around Time), CARDIAC T
Troponin T, CARDIAC T



Specific Proteins

Immunoglobulin E



Thyroid Function

Antibodies to TSH receptor
Antibodies to thyroid peroxidase
Antibody to thyroglobulin (anti-Tg)
Elecsys T3
Free Triiodothyronine
hCT - human calcitonin

Tumor Markers

AFP α1-fetoprotein
Cancer Antigen 125
Cancer Antigen 15-3 II
Carbohydrate Antigen 19-9
Carcinoembryonic antigen
Carcinoembryonic antigen
Elecsys free PSA
Elecsys total PSA
Human epididymal protein 4

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